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Trimethylaminuria (TMAU), often known as “fish odor syndrome,” is a metabolic disorder caused by the body’s inability to break down trimethylamine, a compound with a distinctive odor. The condition results from a deficiency of the enzyme FMO3, which normally converts trimethylamine into an odorless form. Individuals with TMAU may experience strong body odor despite good hygiene, leading to emotional distress and social challenges. Diagnosis typically involves genetic testing and urine analysis to measure trimethylamine levels. While there is no cure, various management strategies can help reduce symptoms. Dietary modification plays a major role, with individuals avoiding foods rich in trimethylamine precursors, such as certain fish, eggs, and legumes.

Supplements like activated charcoal or copper chlorophyllin may help reduce odor in some cases. Good gut health is also important, as certain intestinal bacteria produce trimethylamine. Behavioral support and counseling can help individuals cope with the psychosocial impact. Research continues into targeted…

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